Healthy Pet Network

Supportive Data for Dr. Plechner's Work

Supporting Data



    Written articles, case studies, research and other information which supports and
   validates the research, findings, assertions, and data of Dr. Plechner, DVM



Vol 4 No 4 Annual Summary Edition 2006/07 on this website:

You should be able to click this link to read the article. Please let me know if you need anything else!

There are two references to your research:


To stop HIV progression to AIDS, we needed to find a way to suppress and control the inflammatory cytokines that drive the TH2 arm of the immune system. The inflammatory cytokines we know about today are NF-Kappa B, TNF-a and IL-6 but there could be more that will be discovered in due time. It was not only Alfred Plechner, DVM, whose 30 plus years of treating over 35,000 dogs, cats and other pets with prednisolone and thyroid that finally opened our eyes to scrapping the disease model of the past 25 years that HIV is pathogenic and directly causes immune deficiency but also the research in Germany of Albrecht Ulmer et al in a controlled study that demonstrated that even a low dose of just 5 mg daily of prednisolone could single handedly keep the CD4 counts high and AIDS at bay over a 2 year period.


Hydrocortisone cream shrinks tumor on my dog

West Allis, WI: by the Editor - Conrad LeBeau. My 8 yr old fox terrier, named Coska, developed a tumor under his right leg a few years ago that gradually grew to about the size of a quarter and showed signs of irritating the dog. Early in November, I began applying hydrocortisone cream on or near the tumor. After about a month, it shrink to about the size of a small pea and has stayed at this size for several weeks. I recently started adding 1/4 teaspoon of bee propolis to his daily feed based on research of its anticancer properties and promotion of intestinal health (increases IGA). The bee propolis seems to have improved the appearance of the stools and the dog acts more energetic and playful. It is too early to determine if this combination will lead to a complete remission of the growth. This is a scaled down version of Alfred Plechner's protocol that he used on dogs and cats for several years to treat cancer and other health conditions."





Journal of Immunology.....University of Tenn. School of Veterinary Medicine

Hyperestrinism in Dogs

       Hyperestrinism in dogs may be a new and emerging disease entity.  In sample submissions to the Clinical Endorinology Service (2005) at The University of Tennessee, 40% of adrenal panels had elevated estradiol levels present (>70 pg/ml).29  In hyperestrinism cases, estradiol is the estrogen that is increased, ACTH stim and LDDS tests are usually normal for cortisol, thyroid function is normal or controlled, liver problems are frequent and typical (very elevated alkaline phosphatase, hepatomegaly, steroid hepatopathy, hyperechoic liver by ultrasound), PU/PD is frequent, panting may be present, haircoat problems often are present, skin biopsy results suggest an endocrinopathy, there is no change in estradiol level in response to ACTH stim or LDDS tests as currently conducted, resistance to mitotane may occur and increase often occurs in response to trilostane.  Effective treatment options for hyperestrinism in dogs is limited at the present time, and drugs that could be expected to be efficacious (aromatase inhibitors – excluding melatonin) often are limiting due to cost.  Melatonin and phytoestrogen treatment may be effective for the above listed reasons.  Mitotane will likely be effective if the source of estradiol is the adrenal tissues.  Trilostane treatment frequently results in increased estradiol levels,29 and this may be a reason why less than effective treatment with the drug sometimes occurs.



Journal of the American Animal Hospital Association
Volume 45 | Issue 5 (2009 Sep-Oct)


 Elevations in sex hormones in dogs with sudden acquired retinal degeneration syndrome (SARDS).

J Am Anim Hosp Assoc. 2009 Sep-Oct;45(5):207-14.

Renee T Carter1, Jack W Oliver, Rebecca L Stepien, Ellison Bentley
1 Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Skip Bertman Drive, Baton Rouge, Louisiana 70803, USA.


Dogs diagnosed with sudden acquired retinal degeneration syndrome (SARDS) commonly are presented with concurrent clinical, physical, and historical findings consistent with hyperadreno-corticism (HAC) at the time of vision loss. Thirteen dogs diagnosed with SARDS on the basis of complete ophthalmic examination and extinguished bright-flash electroretinogram were evaluated for steroid hormonal abnormalities. Signalment, case history, physical examination, and clinicopathological findings were recorded. Serum cortisol and sex-hormone concentrations were measured before and after adrenocorticotropic hormone (ACTH) stimulation. Clinical signs of HAC, systemic hypertension, and proteinuria were commonly found in dogs with SARDS. Elevations in one or more sex hormones were found in 11 (85%) of 13 dogs (95% confidence interval [CI] 65% to 100%); cortisol was elevated in nine (69%) of 13 dogs (95% CI 44% to 94%). A minority of dogs (three [23%] of 13; 95% CI 0.2% to 46%) exhibited only an increase in adrenal sex hormones. Only one dog had completely normal ACTH stimulation test results. Symptoms of HAC were associated with abnormal ACTH stimulation results. Routine ACTH stimulation testing to evaluate cortisol and sex hormones, blood pressure screening, and urinalysis are recommended in these animals.

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Silent Pet Epidemic READ MORE

Forty years ago pets lived to 15–20 years and more. Today the average life span of a Golden Retriever is just 7 years. Forty years ago pets rarely got human degenerative diseases such as diabetes, cancer and autoimmune disorders. A recent study (2005, Morris Animal Foundation) showed nearly 50% of older pets will die from cancer. Dr. Martin Goldstein, DVM, a holistic vet in N.Y., told us he now sees puppies under 1 year old with cancer. Why are our pets now experiencing illnesses of epidemic proportions?

Early in his 35-year practice, Alfred Plechner, DVM, “…became dissatisfied with just
treating the superficial signs of health problems…the conventional treatment I trained
for at veterinary school had little impact on pets seemingly more susceptible to disease
and allergies and who seemed to be living shorter and sicker lives
.” (Plechner, DVM,
Alfred, Pets at Risk: From Allergies to Cancer, Remedies for an Unsuspected Epidemic,
New Sage Press, 2003, p. 3.) Dr. Plechner’s frustration led him to use his own time and
money on clinical research to discover why this was happening. He uncovered a hidden
adrenal gland defect that caused an endocrine-immune system imbalance
. His research
showed this endocrine-immune system dysfunction was caused primarily by poor genetics